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Is it safe to take estrogen alone? " Estrogen alone for breast cancer is highly protective, and if it is taken for women less than age 60 and that's the age when hormone replacement therapy with estrogen should begin it's very safe. It actually reduces heart attacks and does not increase any stroke or clotting. Can you take hormone replacement if you smoke? Not necessarily; smoking alone doesn't disqualify you from hormone replacement therapy (HRT). But don't take HRT just for the prevention of cardiovascular disease, especially since smoking already puts you at a higher risk for stroke and heart disease.
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