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What causes disulfiram reaction? These effects are caused by accumulation of acetaldehyde, a major but toxic metabolite of alcohol formed by the enzyme alcohol dehydrogenase. A variety of other drugs cause disulfiram -like reactions upon consumption of alcohol as unintended drug interactions and side effects. What are the side effects of Antabuse? Common side effects of Antabuse include: drowsiness, tiredness, headache, metallic or garlic-like taste in the mouth, skin rash or acne, impotence, and. swollen or sore tongue. How long does 500mg of Antabuse stay in your system? This is because of the Antabuse half-life, which is between 60 to 120 hours. The Disulfiram half-life means that this is the amount of time it takes for half the drug to exit the body. As much as 20% of one dose of Antabuse can remain in the body for a week, or even longer in some cases.
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