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In the pediatric population, the leading causes of heart failure are significantly different from those in the adult.
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Further, bisoprolol is not a substrate for P-glycoprotein efflux protein.
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Chronic obstructive pulmonary disease (COPD) frequently coexists in patients with chronic heart failure (CHF) and is a key factor for beta blocker underprescription and underdosing.
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The 20 mg dosage regimen was more effective than that of 5 mg and 10 mg.
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Baseline demographics, medical history, cardiac risk factors, and cardiac history are evaluated.
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Differences between groups in proportions of patients with events or numbers of events were analyzed by χ 2 test.
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In vitro studies have shown that bisoprolol is also metabolized by CYP2D6 though this does not appear to be clinically significant.
The rationale for the most successful medical treatment modalities for cardiomyopathies is therefore based on altering these neurohormonal responses.
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