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What is the medicine that makes your pee orange? Medications. Rifampin (Rifadin, Rimactane), an antibiotic often used to treat tuberculosis, can turn urine reddish orange — as can phenazopyridine (Pyridium), a drug that numbs urinary tract discomfort, and laxatives containing senna. Will doxycycline treat a UTI? Doxycycline is often used to treat bacterial infections in dogs, cats, and other animals. Doxycycline may be prescribed to treat several bacterial infections, such as leptospirosis, urinary tract infections (UTI), toxoplasmosis, erlichiosis, or mycoplasma.
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